Since these food supplements and food products have not gone through the evaluation process of the FDA, the agency cannot assure its quality and safety
Moreover, in a randomized study with T2DM patients, liraglutide combined with insulin significantly improved glycemic control, reduced oxidative stress markers, increased antioxidant levels, and lowered pro-inflammatory markers, MCP-1 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), as compared to insulin alone [98]
Another double-blind RCT evaluating the administration of HA 120mg/d for 12 weeks reported a significant reduction in wrinkles and an increase in stratum corneum water content and skin elasticity and thickness.20 Similar results had been observed in earlier RCTs (Table 4)2123 and prospective studies.24 A study of the benefits of an oral eggshell supplement, which contains HA and collagen, showed an improvement in skin elasticity, a reduction in skin pigmentation, and very high patient satisfaction with facial softness, skin hydration, and hair and nail appearance.25 A double-blind RCT (n=88) with similar characteristics reported a reduction in periocular wrinkles and improved hair thickness and growth.26 Oral Tranexamic Acid The plasmin inhibitor tranexamic acid (TA) is a potent anti-inflammatory and depigmenting agent
They seldomly suffer from lipid peroxidation and subsequent ferroptosis originating from oxidative phosphorylation 49
Most protocols recommend weekly or biweekly sessions initially, followed by monthly maintenance
