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989-1002, Duncan, Jessica, et al
Doxorubicin Treatment with L-carnitine may protect heart cells against the toxic side effects of doxorubicin, a medication used to treat cancer, without reducing the effectiveness of this chemotherapy agent
This is the first initiation step in the process of peroxidation of lipids (Fig
Building on these findings, we combined functional and phenotypic cell death assessments, transcriptomic data, and syngeneic tumor models in murine melanoma and colorectal cancer cell lines to demonstrate that lipophilic statins uniformly promote ferroptosis by depleting GPX4 and that statin-induced ferroptosis augments antitumor immune responses following -PD1 checkpoint blockade
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