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10.1038/s41467-022-30559-2 258 ZhuL.WangZ.HanW.XuA

50% of the bodys storage of vitamin B12 is kept within the liver, no matter how it is administered, so if the liver is sick, in all likelihood, a person can suffer B12 deficiency

It is characterized by progressive biliary inflammation and fibrosis, often leading to cirrhosis, portal hypertension, and liver failure, with liver transplantation remaining the only life-prolonging treatment for advanced cases 59,60

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These investigations often entail observing cancer progression in affected animals via the supply of polyphenols using diverse approaches (482, 483)