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J.MiguelV.BenavidesG

In addition, pathophysiological processes include both excitotoxicity of VPA metabolites and a decrease in gene transcription due to a decrease in the level of histone acetylation, which is accompanied by a loss of GABAergic (gamma-aminobutyric acid) neurons in the striatum as a pathological hallmark of Huntingtons disease [13,104]

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Medication Interactions Gastric Acid Inhibitors Gastric acid inhibitors include proton pump inhibitors, such as omeprazole (Prilosec) and lansoprazole (Prevacid), and histamine 2-receptor antagonists, such as cimetidine (Tagamet) and ranitidine (Zantac)

Updated June 15, 2026