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In preclinical studies, GLP-1R agonists have been demonstrated to improve hepatocyte mitochondrial function and hepatic insulin sensitivity [67], and reduce adipose tissue lipotoxicity both due to body-weight loss and mechanisms independent of body-weight reductions [68]

No significant benefits of citicoline supplementation over placebo were found at 90 days (end of treatment period) and 180 days

Conclusions: Cere treatment was well tolerated and resulted in significant improvements in the global score two months after the end of active treatment

Most respondents were of European ancestry (78.3%), although the study also included substantial representation from Latino (12.9%) and African American (4.2%) ancestries