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Phase 3 trials (large human trials with thousands of participants) are still running, and Lilly plans to apply for regulatory approval once the TRIUMPH programme publishes its results across 2026

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Likewise, GLP-1 inhibits VSMC dedifferentiation by regulating mitochondrial dynamics via enhancing adiponectin (APN) expression, which in turn promotes the phosphorylation of AMPK and SIRT1 in VSMC [126, 127]