More frequent, slower dose increases allow for improved outcomes with lower risk of side effects
Cell cycle distribution significantly affects cellular radiosensitivity, with cells in each phase demonstrating different inherent radiosensitivities (34)
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However, this effect was seen in a mutated form of IDE with limited cysteines, and whether it is physiologically relevant is uncertain as C110 is not nitrosylated in wild type IDE containing all 13 cysteines
APAP overdose could cause ALF, but in several studies, repeated exposure to APAP led to autoprotective effects (Eakins et al., 2015)
