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Those showing minimal early response may need dose adjustments, medication switching, or acknowledgment that their particular physiology responds less robustly to these receptor agonist approaches

Prospective studies involving pregnant and lactating females should be performed to assess the long-term effects of SSRIs on fetal and neonatal development

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Furthermore, this population had high utilization of medications known to improve outcomes (for example, 93% were on statins, 92% were on Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, among others)