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Although drugs such as OCA and Elafibranor have pharmacological benefits in treating MAFLD, these combinations suffer from poor solubility during oral administration and severe side effects, which severely limit their clinical application

[DOI] [PubMed] [Google Scholar] Lin HV, Efanov AM, Fang X, Beavers LS, Wang X, Wang J, Valcarcel ICG, Ma T, 2016

Read the full app note: To view or add a comment, sign in Non-animal models (NAMs) are critical tools for drug development

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But my experience is that patients have a hard time torturing the 14 mg dose