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Such a role in mammals is controversial, although sirtuins are energy-sensing regulators involved in signaling pathways that could play important roles in delaying the onset of age-related diseases (e.g., cardiovascular disease, cancer, dementia, arthritis)

The most rigorous bone-specific RCT to date - Hansen et al

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Mice were housed under a 12-h light/12-h dark cycle (lights on from 7:00 AM to 7:00 PM), at an ambient temperature of 2123 C and relative humidity maintained between 3070%