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For patients who travel frequently or have unpredictable schedules, oral or topical options may be more practical during certain periods

Abbreviations BBB: Blood-brain barrier CGRP: Calcitonin gene-related peptide CM: Chronic migraine CNS: Central nervous system CSD: Cortical spreading depression DMEM: Dulbeccos modified Eagles medium FBS: Foetal bovine serum GLP-1R: Glucagon-like peptide-1 receptor IGF-1: Insulin-like growth factor-1 IS: Inflammatory soup LPS: Lipopolysaccharide NTG: Nitroglycerin PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PMSF: Phenylmethylsulfonyl fluoride RT: Room temperature TNC: Trigeminal nucleus caudalis References May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment

Every time we eat, a specific hormone is automatically released in our body that gives a feeling of fullness

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SUSTAIN 1 to 5 trials showed a weight loss of 3.5 to 4.3 kg in patients taking 0.5 mg and 4.5 to 6.4 kg in patients taking 1 mg, compared to 15.3 kg in patients taking 2.4 mg of Wegovy once weekly