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The upper intake limit for vitamin D is 4,000 IU daily for adults, with higher doses requiring monitoring for toxicity

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View published research Sikiric, P., et al

Monaghan DT, Bridges RJ, Cotman CW (1989) The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system

According to the Mayo Clinic, some of these possible interactions include: Substrates for cytochrome P450 2C9, such as Valium (diazepam) and Jantoven (warfarin) Some diabetes medications Evista (raloxifene) Olysio (simeprevir) Rapamune (sirolimus) Other medications, such as those that treat allergies, high cholesterol, anxiety, and cancer, could also interact with milk thistle, according to Mount Sinai