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M., Lu, H., Wheaton, A

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[7] The protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell death and increases resistance to toxic challenges, especially oxidative stress

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Weight loss follows a progressive pattern, with 35% reduction by 12 weeks and potentially 1015% or more by 612 months in responders