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These medications may increase appetite by antagonizing histamine H1 and serotonin 5-HT2C receptors, interfere with glucose metabolism, and promote central fat accumulation through dysregulation of hypothalamic signaling and activation of the endocannabinoid system (54)

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Further studies have found that hyperglycaemia can impair the antioxidant defence system by inhibiting Nrf2 activity, while GLP1RA can reverse this change by activating the Nrf2 signalling pathway to enhance antioxidant gene expression, thereby promoting ROS clearance

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