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Combination Approach To treat melasma, you can use a combined approach that includes: Topical treatments like topical glutathiones, azelic acid, niacinamide, vitamin c etc Strict sun protection Oral glutathione supplements paired with Vitamin C and alpha-lipoic acid Results Timeline Glutathione for melasma takes 3-6 months to show visible improvements

Warming the solution slightly by holding the syringe in your closed hand for 30 seconds before injecting can also reduce irritation

doi: 10.1007/s10787-025-02035-y, 80