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doi:10.1006/enrs.1999.4003

Numerous clinical studies have confirmed that elderly individuals with low serum Vitamin D levels are more prone to exhibit aging-associated features such as xerosis, pruritus, increased wrinkling, and dyschromia, along with higher incidences of cutaneous infections and inflammatory dermatoses (e.g., senile eczema, psoriasis) [49,50,51,52].Emerging evidence further suggests a positive correlation between Vitamin D deficiency and the risk of non-melanoma skin cancer (NMSC), underscoring its potential role in maintaining immune surveillance and cutaneous tumor defense [53]

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Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis