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Important safety considerations include the recommendation to discontinue semaglutide at least 2 months before a planned pregnancy, as specified in FDA labeling

[10] [11] Phase 2 trial data published in the New England Journal of Medicine in 2023 (Jastreboff et al.) demonstrated substantial effects on body weight and metabolic parameters, though the full benefitrisk profile is still being established in ongoing Phase 3 trials

GLP-1 receptors, in particular, exist in regions critical for mood regulation, including the prefrontal cortex, amygdala, hippocampus, and hypothalamus

Taking the tablet at the same time each morning, on an empty stomach, and adhering strictly to the 30-minute waiting period before eating or drinking is essential for adequate absorption