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The underreported symptoms are leads that came from patients themselves, unprompted and clinicians could potentially pay attention to them, he said

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In the phase 2 study published in the New England Journal of Medicine, gastrointestinal symptom rates nearly doubled when participants jumped directly to 8mg instead of titrating gradually from 1mg

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There is a need for more phase III studies to provide sufficient clinical evidence for the effectiveness of retatrutide, as current evidence is limited to phase II studies and has yet to prove its worth in a larger population