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Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients

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As they can react with the chemotherapy drug and change the treatment outcomes

[7] [9] Patients with hemochromatosis or other iron overload disorders should not receive large doses of ascorbic acid, as it can enhance iron absorption and exacerbate tissue deposition

ACS Nano 14 (10), 1350013511