Source: DailyMed (Phentermine), DailyMed (Adderall) Drug interactions of phentermine vs

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The SURMOUNT-4 trial showed even steeper rebounds with tirzepatide, with participants regaining more than 50% of their weight loss over 52 weeks after stopping
Rep Biochem Mol Biol 7:18 Zambrano S, Blanca AJ, Ruiz-Armenta MV, Miguel-Carrasco JL, Revilla E, Santamara C, Mate A, Vzquez CM (2013) The renoprotective effect of l-carnitine in hypertensive rats is mediated by modulation of oxidative stress-related gene expression
So those are the guidelines for which that doctors typically follow when they're deciding if they're gonna prescribe these medications