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Compounding this issue, certain mycotoxins have been shown in animal models to suppress the production of Diamine Oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine in the gut

10.1016/j.brainresbull.2017.01.024 Brain Res

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in colonocytes, oxygen consumption with oxidation of butyrate by colonocytes gives CO 2 and ATP, and this is associated with water and sodium absorption 25

In addition, the researchers propose, other factors also may contribute, such as certain medications, minor illnesses (especially gastrointestinal conditions) and perhaps changes in the microbiome that might deplete carnitine from the body