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Its ~1-week half-life is the reason weekly dosing works

But many patients with diabetes also take GLP-1 agonists to support weight loss, as weight loss itself can improve diabetes outcomes

Patients should not inject research-use or online products marketed as retatrutide

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

It analysed more than 600,000 veterans with type 2 diabetes and, compared with patients on non-GLP-1 medications, being on GLP-1s was associated with being 14% less likely to develop a substance abuse disorder (SUD)