The clinical significance of L-carnitine in ameliorating insulin resistance (IR) lies in its intervention in a core pathogenic feature of MASLD: hepatic IR
Part of this comes from weight loss itself (excess adipose tissue actively produces inflammatory signals), and part appears to come from tirzepatides direct metabolic effects
This therapeutic method gets rid of the plateau effect seen in single-agent treatments and gives drug companies a way to place their products differently in the competitive metabolic disease market
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