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First, the glutamate cysteine ligase (GCL) catalyzes the formation of a dipeptide constituted by glutamate and cysteine, and then the GSH synthetase catalyzes the addition of glycine to form GSH[38], the former being the rate-limiting step

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In the present study, we examined the responses of these two small molecules to incretins and assessed the actions of metformin against incretin signaling

Oxidized glutathione (GSSG) is regenerated through a reduction reaction that utilizes NADPH as a coenzyme