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FIGURE 2 4 Mitophagy and metabolic diseases The specific pathogenesis of metabolic diseases has not been conclusively determined, and it is currently believed that potential mechanisms such as ROS surge, abnormal protein structure and function, chronic low-grade inflammation, DNA damage, and insulin resistance are closely related to mitochondrial dysfunction (Matsumura et al., 2023)

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In Drd2 flox/flox mice, striatal GSH was upregulated after quinpirole administration