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However, the recently concluded SAVOR-TIMI 53 trial conducted on patients with T2DM with either a history of established CVD or multiple CVD risk factors, has failed to demonstrate the superiority of saxagliptin over placebo in reducing a composite end point of cardiovascular death, nonfatal MI or nonfatal ischemic stroke when added to usual care [142, 143]

However, recent investigations have illustrated that intake of ketogenic diets may result in various side effects such as cognitive decline and risk of cardiovascular events [19, 20], despite unknown mechanism

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This could help clarify whether the therapeutic effects observed in earlier trials were primarily driven by improvements in metabolic health rather than direct neuroprotective effects

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