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Downregulation of CAV1 reduces the levels of GPX4 and FTH1, increases ROS and Fe 2+ concentrations, promotes ferroptosis, and reduces cancer cell migration and invasion, 171 suggesting that the regulatory pathways of CAV1 and ferroptosis may be potential targets for diagnosis and combination therapy strategies in patients with HNSCC

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To understand the effect of host cell glutathione on existing infections, additional experiments were conducted in which A6 cells were supplemented with 2.5 mM cysteine at 24 hr post infection