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However, while evidence supports NACs therapeutic effect in stable patients with SZ, its efficacy in patients with refractory SZ on clozapine remains inconclusive (Neill et al., 2022

The cyclic lactam structure that defines MT-II has served as a template for subsequent melanocortin-receptor probe development, including the receptor-selective antagonist series reported by Hruby and colleagues in 1995 using bulky aromatic substitutions at position 7 [8]