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Based on these observations, Gregorio Weber pointed out in 1975: From these results it can be definitely concluded that the time-average structure observed by X-ray diffraction is something of an abstraction, since it is not itself widelyor even sparselyrepresented at any given time in the population of molecules Indeed the protein molecule model resulting from the X-ray crystallographic observations is a platonic protein, well removed in its perfection from the kicking and screaming stochastic molecule that we infer must exist in solution

Discussion Interpretation of the Current Evidence The central finding of this review is the imbalance between clinical uptake and clinical evidence

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