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GLP-1 receptor has been identified in human and rodent choroid plexus epithelium, which, when stimulated with the GLP-1 RA exenatide, reduces CSF secretion through a cyclic adenosine monophosphate protein kinasea signaling pathway with subsequent inhibition of Na + K + adenosine triphosphatase ion channel activity (a key regulator of CSF secretion)thereby reducing ICP

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The dose chart maps every common dose to the number of vials needed per month

This is a pre-specified nested study of the IIH:Pressure trial that aimed to determine the effects of exenatide on cognition in a cohort of IIH patients with raised ICP