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In a murine lupus model, oral Lactobacillus acidophilus restored cecal microbiota composition in lupus-prone mice and regulated the Th17/Treg cell balance by decreasing Th17 cells and increasing Treg cell proportions, while enhancing the efficacy of the immunosuppressant tacrolimus [87]

[14] Melatonin exhibits significant inter-individual variability in absorption, metabolism, and therapeutic response, necessitating careful titration and monitoring to achieve optimal outcomes

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