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In rats with cirrhosis, lipopolysaccharide administration precipitated pre-coma and worsened cytotoxic brain edema through the combined effects of hyperammonemia and inflammation

12 A phase 1, dose-finding and expansion study (NCT04214860) was conducted to evaluate combined therapy using APR-246 and venetoclax with or without AZA in AML patients with p53 mutation

Adverse Effects Common: somnolence, anorexia, small increase in blood pressure and pulse

Consequently, this prolongs the feeling of fullness (satiety), reduces appetite, and reduces overall calorie intake subsequently leading to negative energy balance and weight loss 18

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