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To understand the underlying mechanisms, inhibitors targeting the Notch pathway (DAPT) and NF-B pathway (BMS) were also applied to HUVEC and murine CLI models

For 21 weeks, Leiden mice were fed a high-fat diet enriched with LC, NR, or both (COMBI)

The cumulative consequences of these processes induce lipid peroxidation, eventually causing ferroptosis of chondrocytes in OA (Figure 3)