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Additionally, recent studies have identified bacterial DNA in human and mouse adipose tissues 20,21

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3 Oral melanotic macule has to be differentiated from certa i n oth er si m i l a r con d i ti on s exh i b i ti n g hyperpigmentation such as racial pigmentation, post inflammatory hyper pigmentation, endocrinal hyper pigmentations, Anti-malarial drugs, Syndromes such as Peutz-Jeghers syndrome where freckles are seen not only in the oral cavity, but also at the distal extremities, Leopard syndrome where pigmentation is seen all over the body

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