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GLP works best when combined with a larger medical weight management plan that includes health and lifestyle changes, including a nutritious diet and frequent exercise
GLP-1s also make some people feel more tired
Combination pharmacotherapy, while sometimes used in clinical practice, is generally off-label with limited evidence in post-bariatric populations and requires careful monitoring
Why People Use It Cost-effectiveness Availability when branded options are scarce Customizable doses Delivery Formats Sublingual drops Orally disintegrating tablets Nasal spray Solution in vial Pen Concerns A big one: non-FDA-approved treatments
Both agents provided clinically meaningful reductions in HbA 1c (2.6 mmol/mol [0.2%] with SGLT2i and 5.4 mmol/mol [0.5%] with GLP-1 RA)
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