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High glucose levels stimulate hepatic LEAP2 production and secretion [157], and LEAP2 infusion lowers postprandial plasma glucose and GH concentrations [178] while enhancing insulin secretion [59]
Comparative Pharmacology Dual (tirzepatide) vs triple (retatrutide) incretin receptor kinetics, potency, and metabolic breadth
According to their findings, there was a higher risk of the condition in patients prescribed semaglutide compared to those on non-GLP-1 RA medications, warranting further study to assess causality
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