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They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)

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They saw increased cleavage and blastocyst formation rates in both mouse and bovine systems

The European Association for the Study of the Liver (EASL) clinical practice guidelines on Wilson disease note that hepatic copper exceeding 250 mcg/g dry weight is a strong diagnostic criterion for Wilson disease, but subclinical copper accumulation can begin at much lower thresholds in patients with cholestatic or cirrhotic liver disease [2]

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