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Biomarkers in Vitiligo IFN- : A Key Player in Melanocyte Destruction Melanocyte depletion in vitiligo is primarily caused by cytotoxic T lymphocytes (CTLs), with activation of the FasFasL pathway being a key molecular mechanism

Because studies are conducted at different times, with different samples of patients, by different investigators, employing different criteria and/or different interpretations of the same criteria, under different conditions (dose, dosing regimen, etc.), quantitative estimates of treatment response and the timing of response may be expected to vary considerably from study to study

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284 Emerging epigenetic data suggest that GLP-1 RAs may decelerate biological aging via DNA methylation modifications at loci associated with inflammatory and metabolic regulation, consistent with observed reductions in biological age