It happens when fat cells push up against the skin, while the fibrous cords that connect skin to muscle pull down, creating that familiar dimpled texture
Science 217 : 12631265 Town M, Jean G, Cherqui S, Attard M, Forestier L, Whitmore SA, Callen DF, Gribouval O, Broyer M, Bates GP, van't Hoff W, Antignac C 1998 A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis
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Like L-Carnitine, ALCAR is formed naturally in the body, but through the enzymatic addition of an acetyl group to L-Carnitine it is readily converted to ALCAR, and back, depending on the metabolic needs of the cell
The key is early recognition of symptoms, specifically new leg swelling, pain, or redness, and immediate medical evaluation