Although achieving surrogate histopathological endpoints is considered by regulatory agencies to likely translate to improved prognosis, robust evidence is needed to understand if GLP1 agonists reduce the risk of long-term clinical outcomes, such as liver decompensation or HCC, Axel Wester, MD, PhD, assistant professor of medicine at Karolinska Institute, and colleagues wrote
Neither compound has established long-term human safety data

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Instead, it targets something called the activin type II receptor (ActRII)
In these predictions, the peptides are not accurately positioned, leading to clashes