Hemorrhagic strokes, caused by the rupture of a blood vessel, are less common than ischemic strokes, but also play a significant role in the development of VaD
Both amino acids maintain excellent stability under proper storage conditions, though l-citrulline shows slightly better stability in aqueous solutions and higher pH environments
Concurrently, mitochondrial ROS (mtROS) amplifies vascular dysfunction by oxidizing BH4, uncoupling endothelial eNOS, and reducing NO bioavailability while also activating pro-inflammatory pathways (e.g., NLRP3 inflammasome) and stimulating NOX activity, creating continuous oxidative damage (Penna and Pagliaro, 2025)
The glucagon component at higher doses takes time to activate visceral fat stores
doi: 10.1186/1550-2783-11-31