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Similar to patients with diabetes mellitus, those with obesity taking GLP-1 RAs have a significant reduction in MACE, all-cause death, myocardial infarction, and revascularisation, without significant differences in rates of cardiovascular death or stroke

Each receptor limb contributes a distinct downstream effect in preclinical models, and their concurrent activation is hypothesised to produce additive or synergistic metabolic signalling

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[] GDM increases the risk of complications like fetal macrosomia, preeclampsia, and type 2 diabetes postpartum

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