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Most existing drugs in this area are designed to act on one, two, or sometimes three hormone receptors that influence glucose metabolism and appetite

Since B12 is primarily found in animal-based foods such as meat, eggs, and dairy, reduced intake of these foods may gradually affect consistency over time

Csukasi F, Duran I, Barad M, Barta T, Gudernova I, Trantirek L, Martin JH, Kuo CY, Woods J, Lee H, Cohn DH, Krejci P, Krakow D, "The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling", Science translational medicine 10 (459): (2018)