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Because B12 is water-soluble, excess amounts are safely excreted by the body

Moreover, FOXO4-DRI significantly decreased the viability of senescent Leydig cells and dramatically increased their apoptosis rate from 10% to 27%

A.LiotG.KushnarevaY.GraberS.et al (2006)

Deficiency symptoms include anaemia, fatigue, neurological manifestations such as paraesthesia and balance problems, and glossitis, with neurological damage potentially irreversible if untreated

Studies have explored how this compound interacts with copper-dependent enzymes including lysyl oxidase, which plays a critical role in collagen and elastin crosslinking