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Peer review Peer review information Communications Biology thanks Douglas Wallace and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Dry and pruritic skin is a common clinical manifestation of SS, with vasculitis being the second most common cutaneous manifestation, and histological examination usually confirms the diagnosis of leukocytoclastic vasculitis (LCV) [284]

Secondary outcomes included the pharmacokinetic profile of PG-102, assessed using serum concentrationtime data and non-compartmental analyses, with exploratory pharmacodynamic and biomarker endpoints

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The existence of higher molecular mass, a larger number of sp3 carbon atoms, more oxygen atoms, and lesser nitrogen and halogen atoms serve to be hydrogen donors and acceptors with greater molecular rigidity over synthetic compounds