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[Organic and Biomolecular Chemistry, 2003, vol

Two main mechanisms likely cause Wegovy-related tiredness: dramatically reduced calorie intake and effects on the brain areas controlling both appetite and sleep cycles

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It has further surprisingly and unexpectedly been found that multiple agent therapy, wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, for a longer duration, such as measured in minutes, than with a sufficiently high dose of either agent administered as monotherapy that produces an erection sufficient for sexual intercourse