Notably, activation of GLP-1R + neurons in the hypothalamus and brainstem reduces food intake and promotes weight loss
On the basis of several putative modes of action under investigation (for example, neuroprotective and anti-inflammatory properties, regulation of reward pathways), there is an emerging consensus that GLP-1RAs could be repurposed for use in neuropsychiatric conditions 25,26,27,28,29,30,31,32
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40 weeks) and ATTAIN-1 (obesity