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Moreover, a self-adjuvanting gel (SAG) formed by grafting 4-benzimidazole-modified polyethyleneimine (PEI-4BImi) with oxidized dextran which has natural immune-activating properties, can inhibit tumor growth by delivering doxorubicin and the TLR-9 agonist CpG to tumor sites and lymph nodes, promoting antigen presentation and enhancing DC activation within lymph nodes (105)

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It also promotes the expression of proteins related to disulfide bond formation and molecular chaperones and proteins involved in ER degradation and vesicle transport (62)