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Links to other articles on this website with more advanced information and tips related to this medication and/or related topics are provided below, under Related Pages FDA indications According to the Prescribing Information, the wording of the FDA-approved indications for tirzepatide injection (Zepbound ) are as follows (the emphasis below in red has been added by us): ZEPBOUND is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist indicated in combination with a reduced-calorie diet and increased physical activity: to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition