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1 Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from gut enteroendocrine cells in response to food intake, and display insulinotropic actions by stimulating specific G-protein linked GLP-1 receptor (GLP-1R) on the pancreatic cells

Oral GLP-1 RA in Development The success of orally administered semaglutide in clinical trials has led to the development of other oral formulations

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While the precise reason for GLP-1 nausea is not yet clear, it is likely due to the delayed stomach emptying (gastroparesis) or eating too much of the wrong kinds of foods